abstract：:Basal activity of submaxillary gland (SMG) renin is high in female mice that carry the Rnrs allele and is induced to higher levels by treatment with dihydrotestosterone (DHT). To determine whether the difference in basal activity between high (Rnrs/Rnrs) and low (Rnrb/Rnrb) strains is due to enhanced sensitivity of Rn...

journal_title：Biochemical genetics

authors： Wilson CM,Cherry M,Taylor BA,Wilson JD

更新日期：1981-06-01 00:00:00

abstract：:The genetic and cytogenetic locations of the structural gene (Men) for malic enzyme have been determined. Men maps genetically between kar and ry at 51.73 +/- 0.02. Cytogenetically, Men probably lies in the proximal edge of 87D1,2, based on the results of mapping utilizing a number of deficiencies with breakpoints in ...

journal_title：Biochemical genetics

authors： Voelker RA,Ohnishi S,Langley CH,Gausz J,Gyurkovics H

更新日期：1981-06-01 00:00:00

abstract：:The effects of environmental 2-propanol on the in vivo properties of Drosophila alcohol dehydrogenase (E.C. 1..1.1.1.) are presented. Exposed flies were found to exhibit a significant decrease in ADH specific activity with a concomitant increase in the enzyme's relative in vivo stability and concentration. The possibl...

journal_title：Biochemical genetics

authors： Anderson SM,McDonald JF

更新日期：1981-04-01 00:00:00

abstract：:Human cells irradiated with UV light synthesize lower molecular weight DNA than unirradiated cells. This reduction in molecular weight is greater in xeroderma pigmentosum (XP) cells than in normal cells. The molecular weight of DNA is further reduced by the addition of caffeine to XP cells. By several hours after irra...

journal_title：Biochemical genetics

authors： Minka DF,Nath J

更新日期：1981-04-01 00:00:00

abstract：:The structural gene locus specifying subunits of cytoplasmic isoenzymes of phosphoglucose isomerase (PGI) is present in duplicate in many diploid species of Clarkia (Onagraceae), a genus of annual plants native to California. We studied the kinetic properties and molecular weights of a large number of genetically defi...

journal_title：Biochemical genetics

authors： Gottlieb LD,Greve LC

更新日期：1981-02-01 00:00:00

abstract：:Genetic variation at three dipeptidase loci (Dip-A, Dip-B, and Dip-C) in Drosophila simulans was analyzed by starch gel electrophoresis. Dip-A was found to be polymorphic in four populations, while Dip-B and Dip-C were found to be polymorphic in one. The numbers of different alleles found at each respective locus were...

journal_title：Biochemical genetics

authors： Ohnishi S,Voelker RA

更新日期：1981-02-01 00:00:00

abstract：:Patterns of lactate dehydrogenase (LDH) isozymes of tissues from various mouse strains were examined. An interstrain polymorphism for LDH isozymes of liver was established. One phenotype (CBA/Lac and AKR/J mice) yielded a five-banded LDH pattern, another phenotype (DBA/1J, DBA/2J, C57BL/6J and C3H/He) showed a three-b...

journal_title：Biochemical genetics

authors： Khlebodarova TM,Serov OL

更新日期：1980-10-01 00:00:00

abstract：:The interspecies homology of dace supernatant (A2,AB,B2) and mitochondrial (C2) malate dehydrogenase isozymes has been established through cell fractionation and tissue distribution studies. Isolated supernatant malate dehydrogenase (s-MDH) isozymes show significant differences in Michaelis constants for oxaloacetate ...

journal_title：Biochemical genetics

authors： Starzyk RM,Merritt RB

更新日期：1980-08-01 00:00:00

abstract：:Different homozygous lines of similar genotype with respect to G6pd and 6Pgd were shown to have different enzyme activities for G6PD and 6PGD. Crosses between high and low lines suggested that there were modifying genes present on the autosomes, while others were probably located on the X chromosome. Allelic variation...

journal_title：Biochemical genetics

authors： Bijlsma R

更新日期：1980-08-01 00:00:00

abstract：:RNase-sensitive DNA polymerase activity (RSDP) was tested in different cell fractions of Neurospora crassa cell types and its morphological mutants. This RSDP was found localized in the microsomal pellet fraction and absent in the purified nuclear pellets isolated from different N. crassa cell types: conidia, germinat...

journal_title：Biochemical genetics

authors： Dutta SK,Mukhopadhyay DK,Bhattachryya J

更新日期：1980-08-01 00:00:00

abstract：:In flowers of Dianthus caryophyllus (carnation), the gene I is concerned with a discrete step in flavonoid biosynthesis, Genotypes with recessive (ii) alleles produce yellow flowers, which contain the chalcone isosalipurposide (naringenin-chalcone-2'-glucoside) as the major petal pigment, but in genotypes with wild-ty...

journal_title：Biochemical genetics

authors： Forkmann G,Dangelmayr B

更新日期：1980-06-01 00:00:00

abstract：:The locus for sorbitol dehydrogenase (SORD, E.C. 1.1.1.14) has been shown to segregate with hexosaminidase A and mannose phosphate isomerase in a series of human-Chinese hamster somatic cell hybrids. Cytogenetic analysis supports the assignment to chromosome 15 and further defines the gene locus to the region 15pter l...

journal_title：Biochemical genetics

authors： Donald LJ,Wang HS,Hamerton JL

更新日期：1980-06-01 00:00:00

abstract：:A bioautographic procedure has been developed for the visualization of the isozymes of dihydrofolate reductase (DHFR, E.C. 1.5.1.3). In addition to detecting electrophoretically separated enzymes, bioautography was utilized to visualize DHFR after isoelectric focusing on polyacrylamide gels. Both zone electrophoresis ...

journal_title：Biochemical genetics

authors： Naylor SL,Townsend JK,Klebe RJ

更新日期：1980-02-01 00:00:00

abstract：:Investigations of an euploid series of castor bean, Ricinus communis L., Consisting of haploid, diploid, and tetraploid individuals, was performed to determine the value of such a series in studying the biochemical consequences of genome multiplication. The effects of euploidization of the nuclear genome on the biosyn...

journal_title：Biochemical genetics

authors： Timko MP,Vasconcelos AC,Fairbrothers DE

更新日期：1980-02-01 00:00:00

abstract：:The acidic proline-rich proteins (Pr) showing genetic polymorphism were purified from human parotid salivas by gel filtration and ion exchange chromatography. Molecular weight determinations, amino acid composition analyses, and polypeptide mapping experiments indicate that the Pr 3 protein is a fragment of the Pr 1 p...

journal_title：Biochemical genetics

authors： Karn RC,Friedman RD,Merritt AD

更新日期：1979-12-01 00:00:00

abstract：:The segregation of human lysosomal arylsulfatase A (ARS-A) has been evaluated in 50 primary hybrid clones derived from four separate fusions involving WBCs from two unrelated individuals and three hamster cell lines. ARS-A was expressed in the hybrids as a dimeric molecule of very similar or identical subunits. The ex...

journal_title：Biochemical genetics

authors： Bruns GA,Mintz BJ,Leary AC,Regina VM,Gerald PS

更新日期：1979-12-01 00:00:00

abstract：:Phosphoglucomutase (PGM) of adult stage in Drosophilia melanogaster has been characterized by gel filtration, ion-exchange chromatography, and isoelectric focusing. The two common electrophoretic variants, PGMA and PGMB, differ with respect to their kinetic and stability parameters. PGMA is more thermostable than PGMB...

journal_title：Biochemical genetics

authors： Fucci L,Gaudio L,Rao R,Spanò A,Carfagna M

更新日期：1979-10-01 00:00:00

abstract：:Electrophoretic variation is described for malic enzyme (ME) for the first time in brook trout (Salvelinus fontinalis). Since the quaternary structure of ME was not clear from examination of banding patterns in brook trout alone, ME phenotypes in rainbow trout (Salmo gairdneri)X brook trout hybrids as wel as in esoci...

journal_title：Biochemical genetics

authors： Stoneking M,May B,Wright JE Jr

更新日期：1979-08-01 00:00:00

abstract：:The concentration of D-beta-aminoisobutyric acid (D-BAIB) in the liver and kidney was twice as high and dropped more slowly in the female mouse than in the male after an intraperitoneal injection of thymine. The concentration of beta-alanine, formed from uracil by the same enzyme system catalyzing formation of D-BAIB ...

journal_title：Biochemical genetics

authors： Miyake M,Kanazawa A,Kakimoto Y

更新日期：1979-08-01 00:00:00

abstract：:Techniques are presented to detect 23 isozyme loci in the long-lived perennial plant, ponderosa pine. Meiotically derived megagametophyte from seeds is used to examine directly the segregation of allelic variants. Approximately seven seeds were initially examined for 12 enzymes from each of 47 trees from ten stands th...

journal_title：Biochemical genetics

authors： O'Malley DM,Allendorf FW,Blake GM

更新日期：1979-04-01 00:00:00

abstract：:The quantitative and qualitative distributions of gangliosides were determined in the cerebrum, cerebellum, and brain stem of five inbred strains (C57BL/6J, DBA/2J, LG/J, C3H/HeJ, BALB/cJ) of mice at 21 days of age. Genetic differences were found among the strains for wet weight, absolute amount of gangliosides per re...

journal_title：Biochemical genetics

authors： Seyfried TN,Glaser GH,Yu RK

更新日期：1979-02-01 00:00:00

abstract：:An enzyme catalyzing the transfer of the glucosyl moiety of UDP-glucose to the 3-hydroxyl group of cyanidin has been demonstrated in petal extracts of Silene dioica mutants with cyanidin-3-O-glucoside in the petals. This transferase activity was also present in young rosette leaves and calyces of these plants. The hig...

journal_title：Biochemical genetics

authors： Kamsteeg J,van Brederode J,van Nigtevecht G

更新日期：1978-12-01 00:00:00

abstract：:The nucleoside monophosphate kinases, adenylate kinase (AK), guanylate kinase (GUK), and uridine monophosphate kinase (UMPK), were studied electrophoretically and quantitatively in density gradient fractions of human red cells from normal adults which contain red cells of differing mean age. The enzymes were found to ...

journal_title：Biochemical genetics

authors： Jamil TP,Swallow DM,Povey S

更新日期：1978-12-01 00:00:00

abstract：:UMPK 3 is a rare variant of the polymorphic enzyme of human red cells, uridine monophosphate kinase. This homozygote phenotype was detected among the Warao Indians of Venezuela. The UMPK 1 and UMPK 3 enzymes were partially purified following the method described by Tend et al. (1976). The biochemical and kinetic param...

journal_title：Biochemical genetics

authors： Gallango ML,Müller A,Suinaga R

更新日期：1978-12-01 00:00:00

abstract：:In corn seedlings (Zea mays L.) homozygous for the mutation gl5, the surface waxes are characteristically altered. In this mutant the main wax constituents (83.5%) are aldehydes while in the normal waxes alcohols predominate (62.7%). Moreover, in the normal waxes aldehydes and alcohols are made up mainly of the C32 te...

journal_title：Biochemical genetics

authors： Bianchi G,Avato P,Salamini F

更新日期：1978-10-01 00:00:00

abstract：:The molecular weight forms of kynurenine formamidase were studied both gentically and biochemically. Formamidase I (native molecular weight 60,000) was purified using (NH4)2SO4 and pH fractionation, DEAE-cellulose chromatography at two different pH's, hydroxylapatite chromatography, and Sephadex G-100 gel filtration. ...

journal_title：Biochemical genetics

authors： Moore GP,Sullivan DT

更新日期：1978-08-01 00:00:00

abstract：:We extracted the yellow melanin (phaeomelanin), black melanin (eumelanin), and mixed type of melanin from dorsal hair of dominant yellow (Ay/a), non-agouti (a/a), and agouti (A/A) mice, respectively. Spectrophotometric and fluorescence spectrophotometric analysis demonstrated that the yellow melanin was qualitatively ...

journal_title：Biochemical genetics

authors： Ikejima T,Takeuchi T

更新日期：1978-08-01 00:00:00

abstract：:Inheritance of gliadin components unique to three different varieties of common wheat (Triticum aestivum L.) was studied in F1 and F2 seeds of intervarietal crosses using protein patterns obtained by polyacrylamide gel electrophoresis in aluminum lactate buffer (pH 3.2). The patterns of F1 seeds of the crosses Cheyenn...

journal_title：Biochemical genetics

authors： Mecham DK,Kasarda DD,Qualset CO

更新日期：1978-08-01 00:00:00

abstract：:It is shown that the gene controlling the synthesis of the organ-specific S-esterase of Drosophila virilis ejaculatory bulbs is located on the second chromosome (at approximate position 192.1 +/- map units). The cells of the genital imaginal disks are determined for the synthesis of S-esterase 10-12 hr after the secon...

journal_title：Biochemical genetics

authors： Korochkin LI,Matveeva NM,Kuzin BA,Karasik GI,Maximovsky LF

更新日期：1978-08-01 00:00:00

abstract：:Eight Drosophila melanogaster strains, seven homozygous for AdhF alleles and one for an Adh-null mutant, were compared for ADH activity in males and adult mortality on ethanol-supplemented food. The strains differed considerably in these qualities. A positive correlation was found between ADH activity and LD50. The re...

journal_title：Biochemical genetics

authors： Kamping A,van Delden W

更新日期：1978-06-01 00:00:00

abstract：:Nineteen inbred strains of the laboratory rat (Rattus norvegicus) were investigated for genetic differences by starch and agarose gel electrophoretic techniques. For six out of 21 loci, interstrain differences were observed: Tf, 6PGD, Es-1, Es-4, Es-5, and Svp. The variants are briefly described and the allelic distri...

journal_title：Biochemical genetics

authors： Bender K,Günther E

更新日期：1978-06-01 00:00:00

abstract：:Neurospora crassa can utilize numerous compounds including certain amino acids as a sole nitrogen source. Mutants of the nit-2 locus, a regulatory gene which is postulated to mediate nitrogen catabolite repression, are deficient in the ability to utilize several amino acids as well as other nitrogen sources used by wi...

journal_title：Biochemical genetics

authors： Facklam TJ,Marzluf GA

更新日期：1978-04-01 00:00:00

abstract：:Panagrellus redivivus when placed in 7% ethanol or methanol becomes immobile. After 1 hr the animals resume normal swimming and will grow in alcohol. The ability to recover requires ADH activity and translation, but not transcription, as determined by inhibitor studies. Recovery decreases with longer-chain alcohols, w...

journal_title：Biochemical genetics

authors： Kriger F,Burke D,Samoiloff MR

更新日期：1977-12-01 00:00:00

abstract：:The genetic linkage relationships of the human glycosphingolipid beta-galactosidases were determined using human--mouse somatic cell hybrids. A new method was devised for the estimation of human galactosylceramide, lactosylceramide, and GMI-ganglioside beta-galactosidase activities in the presence of their mouse count...

journal_title：Biochemical genetics

authors： Rushton AR,Dawson G

更新日期：1977-12-01 00:00:00

abstract：:Polysomes from 5.5-day and 6.5-day embryonic chick erythroid cells contain messenger RNA (mRNA) which can be translated into products in a cell-free protein-synthesizing system. The products of the cell-free system coelectrophoresed with carrier globin chains from the cells from which the polysomal pellet was isolated...

journal_title：Biochemical genetics

authors： Zagris N

更新日期：1977-10-01 00:00:00

abstract：:A variant of fetal hemoglobin (Hb F-Malta-I) has been detected and quantitated in adult blood with a sensitive radioimmunoassay employing monospecific antisera. The concentration of Hb-F-Malta-I was 0.002-0.05%, with an average value of 0.011%. The ratio of Hb F-Malta-I/Hb F in adults was about 4.8%, compared to a rat...

journal_title：Biochemical genetics

authors： Altay G,Garver F,Bannister WH,Grech JL,Felice A,Huisman TH

更新日期：1977-10-01 00:00:00

abstract：:Skeletal muscle tissues from many species of salmonid fish are known to exhibit a set of three of five isozymes for A4-type lactate dehydrogenase (L-lactate: NAD oxidoreductase, E.C. 1.1.1.27), but the genetic basis for this isozyme system has not previously been assessed. This isozyme system was purified to homogenei...

journal_title：Biochemical genetics

authors： Lim ST,Bailey GS

更新日期：1977-08-01 00:00:00

abstract：:The enzyme UDPglucose:flavonol 3-O-glucosyltransferase is shown to be under the coordinate control of three genes involved in anthocyanin biosynthesis in the aleurone of maize: C, R, and BZ. Of the three, BZ appears to be the structural gene. Data presented here (dosage comparisons, induction in the mutant c-p, and ef...

journal_title：Biochemical genetics

authors： Dooner HK,Nelson OE

更新日期：1977-06-01 00:00:00

abstract：:beta-Glucuronidase (GUS) has become an important enzyme model for the genetic study of molecular disease, enzyme realization, and therapy, and for the biogenesis and function of the lysosome and lysosomal enzymes. The genetics of human beta-glucuronidase was investigated utilizing 188 primary man-mouse and man-chinese...

journal_title：Biochemical genetics

authors： Lalley PA,Brown JA,Eddy RL,Haley LL,Byers MG,Goggin AP,Shows TB

更新日期：1977-04-01 00:00:00

abstract：:A method for detecting two alleles at Np-1 (nucleoside phosphorylase) and three alleles at Es-10 (esterase 10) from mouse blood by cellulose acetate electrophoresis is described. The allelic constitution at these loci for 44 inbred strains and stocks was determined. The location of Np-1 on chromosome 14 was establishe...

journal_title：Biochemical genetics

authors： Womack JE,Davisson MT,Eicher EM,Kendall DA

更新日期：1977-04-01 00:00:00